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Primary arterial hypertension (AH) or essential hypertension (AH) remains one of the most common cardiovascular diseases. A prolonged and persistent increase in blood pressure (BP) leads to damage to target organs, contributing to the development of severe cardiovascular complications (cerebral stroke, myocardial infarction, life-threatening arrhythmias and heart failure), kidney damage (renal failure) and vision and causes high mortality and disability of the working-age population. Annually in the world hypertension is the cause of death of more than 10 million people. In Ukraine, more than 12.6 million people are registered with this disease, or more than 35% of the population. But, among people with high blood pressure (BP), only 52% of patients know about the presence of the disease, less than a third of them are treated, and no more than 15% of patients are effectively treated.
Имеющаяся пандемия COVID-19, вызванная SARS-CoV-2, приобрела масштабы чрезвычайного положения в области мирового здравоохранения. Лечение хронических воспалительных заболеваний кишечника (ХЗОК) согласно стандартам включает применение препаратов 5-аминосалициловой кислоты (5-АСК), кортикостероидов, цитостатиков, а также биологическую терапию. Однако эти методы лечения могут ослабить иммунную систему, которая потенциально подвергает пациентов с ХОЗК повышенному риску инфекций и инфекционных заболеваний, включая COVID-19. Следовательно, пациенты с ХОККом имеют больший риск развития COVID-19 и более тяжелого клинического течения, или даже смерти, по сравнению с населением в целом.
“For the second month, we see an increase in the number of coronavirus diseases. Over the past week, 24,000 new cases were recorded, the week before that there were 16,000, that is, there is a gradual increase. Our experts, together with WHO experts, predict that this year the peak incidence will be at the beginning October... In previous years, it was the end of October - the beginning of November. We are preparing for this in order to provide proper medical care," the minister said.
If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
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