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Пульс - медицинский центр
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"It was an ordinary day, a cold morning. I was sleeping after a night shift and woke up from the fact that massive shelling had begun. A tank unit of 16 tanks approached us. Our armored personnel carrier was shot down before my eyes and I ran to help pull the guys out, but did not I ran a little, there were about seven meters left, I could hear the whistle of shells, explosions and darkness ... I rubbed my eyes from the ground and saw that there was a bare bone in the place of the arm, I thought that I should see what was happening with my legs, if I could move. "I thought that I would die, but I was lying, I realized that I would not die for a long time, that I would live and I had to do something, and I put on a tourniquet," the military man says.
If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
5-ASA preparations have very weak immunosuppressive activity. There are no reports that these drugs are associated with an increased risk of infection, and studies evaluating the safety profile of 5-ASA do not show an increased risk of serious or opportunistic infections. Treatment with 5-ASA should be continued without concern for an increased risk of infection or severe COVID-19. If the patient is in contact with a patient with COVID-19 or develops COVID-19, treatment with 5-ASA should be continued.
The current COVID-19 pandemic caused by SARS-CoV-2 has become a global health emergency. Treatment of chronic inflammatory bowel disease (CIBD) according to the standards includes the use of 5-aminosalicylic acid (5-ASA), corticosteroids, cytostatics, and biological therapy. However, these treatments can weaken the immune system, which potentially puts COPD patients at increased risk of infections and infectious diseases, including COVID-19. Therefore, patients with CVD have a greater risk of developing COVID-19 and more severe clinical course, or even death, compared to the general population.
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