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If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
"На тот момент я считал, что лучше уж смерть, чем быть без конечностей. Был такой случай, что я получил гранату, хотел взорвать себя, сказал товарищам, чтобы отошли, но они сказали: "Нет, если у тебя есть желание, давай вместе с нами". И я ее спрятал. Товарищи меня спасли, тащили через ад. Я им много раз говорил, оставьте меня, где-то среди домов, вернитесь, если я буду жив. Но они сказали, что мы тебя не оставим и тянули. Возле нас разрывались снаряды, а они не испугались, вовремя меня дотянули. Я благодарен товарищам и не имею права их подвести. Должен жить дальше, чтобы они не зря рисковали своей жизнью", - говорит Михаил Юрчук.
Specialists of the Laboratory of Epidemiological Research and Medical Informatics of the State Institution “Institute of Public Health named after A.I. O.M. Marzeeva NAMNU” researched the issues of health status, its subjective feeling, as well as behavior that contributes to health or is risky among people of all ages. Assessment by adolescents and young people of their own health, life satisfaction is important for the development of both preventive programs and directions for promoting health. At the same time, it is also important for the elderly and elderly to maintain an active lifestyle, maintain health, work (self-realization), and overcome the so-called biological determinism. It is reasonable to consider the social environment as an important determinant of health. In this regard, the question of optimizing the social environment arises, since in the absence of a comfortable social environment focused on human development, there are actually no constructive conditions for the formation of good health.
The first and mandatory step in the treatment of hypertension is lifestyle modification (LS), which is aimed at correcting the above risk factors, primarily modifiable ones. A big problem is the choice of the most optimal treatment for hypertension, which can slow down the progression of lesions of the heart, blood vessels, kidneys, brain and eyes. The vast majority of hypertensive patients who seek medical help require combination antihypertensive therapy. At the same time, the most appropriate at the present level is the use of fixed combinations of such drugs.
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