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If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
“For the second month, we see an increase in the number of coronavirus diseases. Over the past week, 24,000 new cases were recorded, the week before that there were 16,000, that is, there is a gradual increase. Our experts, together with WHO experts, predict that this year the peak incidence will be at the beginning October... In previous years, it was the end of October - the beginning of November. We are preparing for this in order to provide proper medical care," the minister said.
The criteria for assessing their own health by young people (25-44 years old - according to the WHO classification) were distributed as follows: almost half of the respondents, regardless of gender, rated their own health as "good"; every 4th of those surveyed - as "very good"; “Mediocre” health was noted by every fifth woman and every tenth person; almost the same was the proportion of respondents who rated their own health as “bad”; the level of subjective assessment of "excellent health" was observed in every tenth man, while in women it was absent.
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