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Treatment with corticosteroids (especially prednisolone ≥20 mg/day or equivalent) is associated with an increased risk of infection. However, it is unclear whether corticosteroid therapy is associated with an increased risk of developing COVID-19 or its complications. Data on budesonide, a topical corticosteroid with low systemic bioavailability, show that these drugs are associated with significantly fewer side effects compared to systemic corticosteroids and their side effects are close to placebo. If possible, corticosteroids should be avoided and a rapid dose reduction considered, and a switch to budesonide is recommended. This must be taken into account, taking into account the risk of exacerbation of CKD. If a patient with COPD is in contact with a person with COVID-19 or develops COVID-19, it is recommended to gradually reduce the dose of corticosteroids, the use of budesonide is preferred, but taking into account the severity of COPD and the risk of exacerbation.

Именно переход на использование в Украине ИПВ для всех доз Календаря прививок должен быть ближайшей задачей по вакцинопрофилактике. Для этого можно использовать несколько механизмов, включая гуманитарную помощь, заключение планируемых прямых договоров с производителями вакцин исходя из потребностей необходимого состава вакцин согласно Календарю, в частности с учетом существования современных комбинированных вакцин с ИПВ, которые могут быть использованы и в более старшем возрасте. При отсутствии комбинированных вакцин с ИПВ можно использовать ИПВ в качестве моновакцины.

So, at the population level, health is a multifactorial phenomenon that includes both an objective and a subjective component. Considering that low self-esteem of health is a factor influencing its formation in young people, their choice of risky behavior, propensity for bad habits and psychological disorders, it is important to take into account the subjective component of health in adolescents and young people. the purpose of early detection of certain deviations in self-esteem or the impact on the formation of health of adverse factors, the effect of which can be minimized.

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Moreover, low vitamin D levels common in patients with CVD may increase the risk and severity of COVID-19. This is because vitamin D increases levels of anti-inflammatory cytokines and reduces viral replication, which in turn can reduce pro-inflammatory cytokines that contribute to lung damage. Despite the lack of evidence demonstrating increased susceptibility to COVID-19, drugs used in the treatment of COPD increase the risk of respiratory tract infections to varying degrees. However, theoretically, some immunosuppressive drugs may have beneficial effects, given that the cause of death in COVID-19 is a cytokine storm leading to acute respiratory failure.


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