Пульс - медицинский центр 
Пульс - медицинский центр
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At present, the risk of increased circulation of vaccine-related polioviruses and associated outbreaks with a low level of vaccination coverage against the background of the use of an oral vaccine is also complicated by military operations in the country, leading to the destruction of the infrastructure of cities and towns, intensive migration and evacuation of the population. Ukraine, and to regions where there are no active hostilities (Chernivtsi, Transcarpathian, Lvov, Volyn regions). These areas were the ones with the lowest polio vaccination rates in 2021.
Specialists of the Laboratory of Epidemiological Research and Medical Informatics of the State Institution “Institute of Public Health named after A.I. O.M. Marzeeva NAMNU” researched the issues of health status, its subjective feeling, as well as behavior that contributes to health or is risky among people of all ages. Assessment by adolescents and young people of their own health, life satisfaction is important for the development of both preventive programs and directions for promoting health. At the same time, it is also important for the elderly and elderly to maintain an active lifestyle, maintain health, work (self-realization), and overcome the so-called biological determinism. It is reasonable to consider the social environment as an important determinant of health. In this regard, the question of optimizing the social environment arises, since in the absence of a comfortable social environment focused on human development, there are actually no constructive conditions for the formation of good health.
Responding to such epidemic challenges is very difficult both organizationally and financially. The result is evaluated over time with well-organized epidemiological surveillance. According to the approved polio outbreak response plan, which arose in early October 2021, it was only possible to start the 1st round of the campaign on February 1, 2022. It was supposed to last 3 weeks and was aimed at vaccinating 140,000 children from 6 months of age with IPV. up to 6 years who missed vaccination according to the Calendar. Almost by the end of the 3rd week of the 1st round, as of February 18, 2022, only 28% of the planned number of children were vaccinated. Therefore, we decided to extend the 1st round for an additional 2 weeks, which again was not performed due to the outbreak of war. Thus, there was no actual response to polio outbreaks.
If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
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