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The first and mandatory step in the treatment of hypertension is lifestyle modification (LS), which is aimed at correcting the above risk factors, primarily modifiable ones. A big problem is the choice of the most optimal treatment for hypertension, which can slow down the progression of lesions of the heart, blood vessels, kidneys, brain and eyes. The vast majority of hypertensive patients who seek medical help require combination antihypertensive therapy. At the same time, the most appropriate at the present level is the use of fixed combinations of such drugs.
Если пациент находится в контакте с человеком COVID-19, необходимо рассмотреть возможность временного отказа от приема тофацитиниба в течение 2 недель. Если у пациента положительный результат теста на SARS-CoV-2 и/или у него развивается COVID-19, необходимо рассмотреть возможность отказа от приема тофацитиниба до тех пор, пока пациент не избавится от инфекции.
The last (seventh) category includes artificial (trophic) changes in facial tissues that occurred in patients with artificial lung ventilation and due to prolonged lying on the stomach. The classifications given were the first descriptions of skin lesions in COVID-19 and therefore different signs were given: those that were caused specifically by COVID-19, and those that arose due to various causes, in particular those associated with the treatment of the disease. Due to the fact that these lesions required different approaches in both treatment and anti-epidemic or precautionary measures, we, based on the experience of all these months of observation of patients, propose a classification of skin lesions associated with COVID-19. lay out like this
If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, discontinuation of biologics should be considered until the patient clears the infection. JAK inhibitors (tofacitinib and others) selectively affect the intracellular JAK/STAT signaling system, which mediates the action of many cytokines involved in the pathogenesis of ulcerative colitis. Unlike genetically engineered biological drugs, inhibition
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