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5-ASA preparations have very weak immunosuppressive activity. There are no reports that these drugs are associated with an increased risk of infection, and studies evaluating the safety profile of 5-ASA do not show an increased risk of serious or opportunistic infections. Treatment with 5-ASA should be continued without concern for an increased risk of infection or severe COVID-19. If the patient is in contact with a patient with COVID-19 or develops COVID-19, treatment with 5-ASA should be continued.
The use of thiopurine (azathioprine and mercaptopurine) reduces the immune response to viruses, which is associated with an increased risk of opportunistic infections. There is limited evidence that they increase the risk of respiratory infections. The risks and benefits should be considered, but most patients can continue on a stable dose. In patients in stable remission, elderly patients and in the presence of concomitant pathology, it is recommended to stop taking thiopurine. During a pandemic, it is recommended to avoid starting thiopurine or increasing the dose, which will allow patients to avoid potential side effects. If the patient is in contact with a COVID-19 person, temporary withdrawal of thiopurine for 2 weeks should be considered. If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, temporary discontinuation of thiopurine may be recommended until the patient clears the infection.
К шестой категории кожных проявлений коронавирусной инфекции ученые относят крапивницу, которая в некоторых случаях может быть предвестником начала COVID-19 . К последней (седьмой) категории можно отнести артифициальные (трофические) изменения тканей лица, возникшие у пациентов с искусственной вентиляцией легких и из-за длительного лежания на животе. Приведенные классификации были первыми описаниями поражений кожи при COVID-19 и поэтому приводились разные признаки: те, что были вызваны именно COVID-19 , и те, которые возникали вследствие различных причин, в частности, связанных с лечением заболевания. В связи с тем, что эти поражения нуждались в различных подходах как в лечении, так и в проведении противоэпидемических или мер предосторожности, мы, исходя из опыта всех этих месяцев наблюдения за больными, предлагаем классификацию поражений кожи, ассоциированные с COVID-19 . выложить следующим образом
In the age group of 44-60 years, 47% of men and 66% of women rated their own health as "good" (p<0.05). A feature of the self-assessment of health of the respondents of this age group was higher levels of subjective assessment of health in women compared to men: about 2% of women subjectively assessed their own health as "excellent"; the proportion of women who rated their health as "mediocre" was two times less compared to men (32% versus 17%; p<0.05). In the group of older people (over 61 years of age), gender characteristics of the distribution of self-assessment of health by respondents were also established. Thus, half of the men surveyed rated their own health as “good”, which was three times more than women (53% versus 18%, p<0.01). In women, on the contrary, the share of those who rated their own health as “mediocre” was 17% higher. Almost every fifth woman of this age considers her own health to be “bad”, while not a single man gave such an assessment. High health scores (“excellent” and “very good”) were absent for both men and women.
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