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Применение тиопурина ( азатиоприн и меркаптопурин ) снижает иммунный ответ на вирусы, что связано с повышенным риском оппортунистических инфекций. Существует ограниченное количество доказательств, что они повышают риск инфекций респираторной системы. Следует учесть риски и преимущества, но большинство пациентов могут продолжать прием стабильной дозы. У пациентов в стадии устойчивой ремиссии, пожилых пациентов и при наличии сопутствующей патологии рекомендуется прекратить прием тиопурина.

The first and mandatory step in the treatment of hypertension is lifestyle modification (LS), which is aimed at correcting the above risk factors, primarily modifiable ones. A big problem is the choice of the most optimal treatment for hypertension, which can slow down the progression of lesions of the heart, blood vessels, kidneys, brain and eyes. The vast majority of hypertensive patients who seek medical help require combination antihypertensive therapy. At the same time, the most appropriate at the present level is the use of fixed combinations of such drugs.

Back in 2002, according to the justification of the Institute, inactivated polio vaccine (IPV) was introduced into the Immunization Calendar of Ukraine for the 1st vaccination against poliomyelitis (children continued to receive OPV for the remaining 5 doses by age). In 2006, this vaccine was also used for the second vaccination. This made it possible to first reduce and then practically stop the cases of vaccine-associated paralytic poliomyelitis in Ukraine. Since then, the issue of switching to a full IPV vaccination scheme in Ukraine has been repeatedly raised, as has been practiced for many years in all European countries, the USA, Canada, and Australia. Currently, this problem is becoming even more urgent, given both the epidemic situation and the prospects for Ukraine's accession to the EU.

Specialists of the Laboratory of Epidemiological Research and Medical Informatics of the State Institution “Institute of Public Health named after A.I. O.M. Marzeeva NAMNU” researched the issues of health status, its subjective feeling, as well as behavior that contributes to health or is risky among people of all ages. Assessment by adolescents and young people of their own health, life satisfaction is important for the development of both preventive programs and directions for promoting health. At the same time, it is also important for the elderly and elderly to maintain an active lifestyle, maintain health, work (self-realization), and overcome the so-called biological determinism. It is reasonable to consider the social environment as an important determinant of health. In this regard, the question of optimizing the social environment arises, since in the absence of a comfortable social environment focused on human development, there are actually no constructive conditions for the formation of good health.

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