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Responding to such epidemic challenges is very difficult both organizationally and financially. The result is evaluated over time with well-organized epidemiological surveillance. According to the approved polio outbreak response plan, which arose in early October 2021, it was only possible to start the 1st round of the campaign on February 1, 2022. It was supposed to last 3 weeks and was aimed at vaccinating 140,000 children from 6 months of age with IPV. up to 6 years who missed vaccination according to the Calendar. Almost by the end of the 3rd week of the 1st round, as of February 18, 2022, only 28% of the planned number of children were vaccinated. Therefore, we decided to extend the 1st round for an additional 2 weeks, which again was not performed due to the outbreak of war. Thus, there was no actual response to polio outbreaks.

Both patients and doctors should be well aware of the need for long-term therapy with periodic monitoring of key indicators and the obligatory achievement of the so-called target levels of blood pressure, that is, stable normalization of blood pressure. Only such an approach to the treatment of patients with hypertension can give a successful result. But at present, as mentioned above, only a very small number of patients with hypertension are treated effectively. In this regard, there is no decrease in the frequency of complications of this disease in Ukraine.

Ингибиторы JAK ( тофацитиниб и др.) селективно влияют на внутриклеточную сигнальную систему JAK/STAT, опосредующую действие многих цитокинов, участвующих в патогенезе неспецифического язвенного колита. В отличие от генно-инженерных биологических препаратов, ингибиторы янус-киназа представляют собой низкомолекулярные синтетические средства, предназначенные для перорального приема. Тофацитиниб рекомендуют назначать пациентам с тяжелым и среднетяжелым течением неспецифического язвенного колита. Ингибиторы JAK могут нарушать вирусный иммунитет. Рекомендуется использовать низкую эффективную дозу для поддержания ремиссии: по возможности 5 мг, вместо 10 мг, два раза в день. Избегайте применения тофацитиниба во время пандемии, если нет других альтернатив. Это позволит пациентам избежать возможных побочных эффектов и частого наблюдения за патологией.

Moreover, low vitamin D levels common in patients with CVD may increase the risk and severity of COVID-19. This is because vitamin D increases levels of anti-inflammatory cytokines and reduces viral replication, which in turn can reduce pro-inflammatory cytokines that contribute to lung damage. Despite the lack of evidence demonstrating increased susceptibility to COVID-19, drugs used in the treatment of COPD increase the risk of respiratory tract infections to varying degrees. However, theoretically, some immunosuppressive drugs may have beneficial effects, given that the cause of death in COVID-19 is a cytokine storm leading to acute respiratory failure.

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